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Sublethal engagement of apoptotic pathways in residual cancer
Summary
This article discusses the role of sublethal engagement of apoptotic pathways in residual cancer. It reviews recent evidence that suggests that sublethal mitochondrial outer membrane permeabilization (MOMP) drives the aggressive features of residual cancer cells and can create new therapeutic strategies to target residual disease. The authors also discuss potential conflicts of interest.
Q&As
What is the purpose of the article?
The purpose of the article is to review recent evidence that sublethal MOMP drives the aggressive features of residual cancer cells while templating a host of unique vulnerabilities, highlighting how failed apoptosis may counterintuitively enable new therapeutic strategies to target residual disease (RD).
What are the authors of the article?
The authors of the article are Shane T Killarney, Stephen W G Tait, Douglas R Green, and Kris C Wood.
What is mitochondrial outer membrane permeabilization (MOMP)?
Mitochondrial outer membrane permeabilization (MOMP) is a critical, regulated step in the apoptotic pathway.
What is the role of sublethal MOMP in residual cancer cells?
The role of sublethal MOMP in residual cancer cells is to drive the aggressive features of the cells while templating a host of unique vulnerabilities.
What therapeutic strategies can be used to target residual disease (RD)?
Therapeutic strategies that can be used to target residual disease (RD) include DNA damage response, drug-tolerant persisters, integrated stress response, and sublethal MOMP.
AI Comments
👍 This article provides a thorough review of the recent evidence that sublethal MOMP drives the aggressive features of residual cancer cells while templating a host of unique vulnerabilities.
👎 The article fails to provide practical advice on how to utilize this information to develop new therapeutic strategies to target residual disease.
AI Discussion
Me: It's about a new study that suggests sublethal engagement of apoptotic pathways in residual cancer cells can drive their aggressive features and lead to therapeutic vulnerabilities.
Friend: Interesting. What are the implications of this article?
Me: Well, the study suggests that incomplete apoptotic commitment can lead to new therapeutic strategies that can be used to target residual diseases. It could also open up new avenues of research in cancer treatment and provide new insights into how cancer cells can become resistant to therapies. Additionally, this research could help scientists identify potential therapeutic targets for residual cancer cells and develop more effective treatments.
Action items
- Research the authors of the article to learn more about their research and expertise.
- Explore the related information provided in the article, such as the MedGen and LinkOut resources.
- Reach out to the authors to discuss the article and any questions or insights you may have.
Technical terms
- Apoptotic Pathways
- A series of biochemical events that lead to the programmed death of a cell.
- MOMP
- Mitochondrial outer membrane permeabilization, a critical, regulated step in the apoptotic pathway.
- Residual Cancer Cells
- Cancer cells that survive treatment and serve as the seeds of eventual relapse.
- Sublethal MOMP
- A degree of MOMP reflective of incomplete apoptotic commitment.
- DNA Damage Response
- A set of processes by which a cell detects and responds to damage to its DNA.
- Drug-Tolerant Persisters
- Cells that are tolerant to multiple therapeutic treatments.
- Integrated Stress Response
- A cellular response to stress that involves the coordination of multiple signaling pathways.