Why do we age?
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2000 Nov 9;408(6809):233-8.
doi: 10.1038/35041682.
T B Kirkwood  1 ,
S N Austad
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Affiliation
1 Department of Gerontology, University of Newcastle, Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, UK.
PMID: 11089980
DOI: 10.1038/35041682
T B Kirkwood  et al.
Nature .
2000 .
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2000 Nov 9;408(6809):233-8.
doi: 10.1038/35041682.
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T B Kirkwood  1 ,
S N Austad
Affiliation
1 Department of Gerontology, University of Newcastle, Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, UK.
PMID: 11089980
DOI: 10.1038/35041682
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The evolutionary theory of ageing explains why ageing occurs, giving valuable insight into the mechanisms underlying the complex cellular and molecular changes that contribute to senescence. Such understanding also helps to clarify how the genome shapes the ageing process, thereby aiding the study of the genetic factors that influence longevity and age-associated diseases.
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Search in PubMed. Search in NLM Catalog. Add to Search. . 2000 Nov 9;408(6809):233-8. doi: 10.1038/35041682. T B Kirkwood  1 , S N Austad. Expand. Affiliation. 1 Department of Gerontology, University of Newcastle, Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, UK. PMID: 11089980. DOI: 10.1038/35041682. T B Kirkwood  et al. Nature . 2000 . Show details. Display options. Format. Search in PubMed. Search in NLM Catalog. Add to Search. . 2000 Nov 9;408(6809):233-8. doi: 10.1038/35041682. Authors. T B Kirkwood  1 , S N Austad. Affiliation. 1 Department of Gerontology, University of Newcastle, Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, UK. PMID: 11089980. DOI: 10.1038/35041682. Cite. Display options. Format. Abstract. The evolutionary theory of ageing explains why ageing occurs, giving valuable insight into the mechanisms underlying the complex cellular and molecular changes that contribute to senescence. Such understanding also helps to clarify how the genome shapes the ageing process, thereby aiding the study of the genetic factors that influence longevity and age-associated diseases. PubMed Disclaimer. Similar articles. Keynote lecture: an update on the what, why and how questions of ageing. Martin GM. Martin GM. Exp Gerontol. 2006 May;41(5):460-3. doi: 10.1016/j.exger.2006.03.009. Epub 2006 Apr 18. Exp Gerontol. 2006. PMID: 16621387 Review. Understanding ageing. Holliday R. Holliday R. Philos Trans R Soc Lond B Biol Sci. 1997 Dec 29;352(1363):1793-7. doi: 10.1098/rstb.1997.0163. Philos Trans R Soc Lond B Biol Sci. 1997. PMID: 9460062 Free PMC article. Review. Evolution of senescence: late survival sacrificed for reproduction. Kirkwood TB, Rose MR. Kirkwood TB, et al. Philos Trans R Soc Lond B Biol Sci. 1991 Apr 29;332(1262):15-24. doi: 10.1098/rstb.1991.0028. Philos Trans R Soc Lond B Biol Sci. 1991. PMID: 1677205 Review. [Extension of life: the apotheosis of the molecular biomedical sciences?]. Vijg J. Vijg J. Tijdschr Gerontol Geriatr. 1990 Oct;21(5):199-204. Tijdschr Gerontol Geriatr. 1990. PMID: 2251720 Dutch. Complex adaptive systems, aging and longevity. Mangel M. Mangel M. J Theor Biol. 2001 Dec 21;213(4):559-71. doi: 10.1006/jtbi.2001.2431. J Theor Biol. 2001. PMID: 11742525 Review. See all similar articles. Cited by. A scalable and tunable platform for functional interrogation of peptide hormones in fish. Moses E, Franek R, Harel I. Moses E, et al. Elife. 2023 Oct 24;12:e85960. doi: 10.7554/eLife.85960. Elife. 2023. PMID: 37872843 Free PMC article. Relationship between dietary macronutrients intake and biological aging: a cross-sectional analysis of NHANES data. Zhu X, Xue J, Maimaitituerxun R, Xu H, Zhou Q, Zhou Q, Dai W, Chen W. Zhu X, et al. Eur J Nutr. 2023 Oct 16. doi: 10.1007/s00394-023-03261-2. Online ahead of print. Eur J Nutr. 2023. PMID: 37845359. Microbes are potential key players in the evolution of life histories and aging in Caenorhabditis elegans . Santos J, Matos M, Flatt T, Chelo IM. Santos J, et al. Ecol Evol. 2023 Sep 25;13(9):e10537. doi: 10.1002/ece3.10537. eCollection 2023 Sep. Ecol Evol. 2023. PMID: 37753311 Free PMC article. Understanding the Impact of Industrial Stress Conditions on Replicative Aging in Saccharomyces cerevisiae . Eigenfeld M, Kerpes R, Becker T. Eigenfeld M, et al. Front Fungal Biol. 2021 Jun 2;2:665490. doi: 10.3389/ffunb.2021.665490. eCollection 2021. Front Fungal Biol. 2021. PMID: 37744109 Free PMC article. Review. Dominant constraints on the evolution of rhythmic gene expression. Cheng Y, Chi Y, Sun L, Wang GZ. Cheng Y, et al. Comput Struct Biotechnol J. 2023 Sep 1;21:4301-4311. doi: 10.1016/j.csbj.2023.08.035. eCollection 2023. Comput Struct Biotechnol J. 2023. PMID: 37692081 Free PMC article. See all "Cited by" articles. Publication types. Review Actions Search in PubMed Search in MeSH Add to Search. MeSH terms. Aging / genetics Actions Search in PubMed Search in MeSH Add to Search. Aging / physiology* Actions Search in PubMed Search in MeSH Add to Search. Animals Actions Search in PubMed Search in MeSH Add to Search. Biological Evolution* Actions Search in PubMed Search in MeSH Add to Search. Energy Intake Actions Search in PubMed Search in MeSH Add to Search. Humans Actions Search in PubMed Search in MeSH Add to Search. Models, Biological Actions Search in PubMed Search in MeSH Add to Search. Reproduction Actions Search in PubMed Search in MeSH Add to Search. Selection, Genetic Actions Search in PubMed Search in MeSH Add to Search. Related information. Cited in Books. LinkOut - more resources. Full Text Sources Nature Publishing Group Ovid Technologies, Inc. Other Literature Sources The Lens - Patent Citations. Medical MedlinePlus Health Information.